ALL THINGS HEMP/CANNABIS

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Cannabinoids are a class of chemical compounds that interact with the endocannabinoid system in the human body, which is involved in regulating a variety of physiological processes including pain, mood, appetite, and memory. The two most well-known cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC is the psychoactive component found in cannabis, responsible for the "high" sensation, while CBD is non-psychoactive and is noted for its therapeutic benefits without inducing intoxication. In addition to these, there are over 100 other cannabinoids such as cannabigerol (CBG) and cannabinol (CBN), each having unique effects and potential health benefits.

The benefits of cannabinoids vary significantly based on their type and concentration. THC has been found to alleviate pain and stimulate appetite, making it useful for patients undergoing chemotherapy or those with chronic pain conditions. CBD, on the other hand, has garnered attention for its anti-inflammatory, anti-anxiety, and anti-seizure properties. Studies have shown that CBD can be effective in treating epilepsy, reducing symptoms of anxiety disorders, and even aiding in the management of neurodegenerative diseases. Other cannabinoids like CBG are being researched for their potential antibacterial and muscle-relaxant properties, while CBN is studied for its sedative effects, which might help in treating insomnia. Thus, the diverse range of cannabinoids presents a broad spectrum of therapeutic possibilities, making them a significant focus in medical research and treatment development.

(CBD)-  Cannabidiol (CBD) is a non-psychoactive cannabinoid found in the cannabis plant, meaning it does not produce the "high" associated with its counterpart, delta-9-tetrahydrocannabinol (THC). CBD has gained significant attention for its potential therapeutic benefits, which include anti-inflammatory, anti-anxiety, and anticonvulsant properties. It interacts with the body's endocannabinoid system, which helps regulate various physiological functions such as pain, mood, and immune response. Clinical studies and anecdotal evidence suggest that CBD can be effective in treating conditions like epilepsy, particularly in cases of drug-resistant childhood epilepsy, as well as anxiety disorders, chronic pain, and even some neurodegenerative diseases. Its safety profile and lack of psychoactive effects make it an appealing option for those seeking the medicinal benefits of cannabis without the intoxicating effects of THC.

Cannabinol (CBN) is a mildly psychoactive cannabinoid that is a derivative of tetrahydrocannabinol (THC), formed as THC degrades over time through exposure to oxygen and heat. Unlike THC, which is known for its strong psychoactive effects, CBN produces a much milder high, if any at all. This transformation process means that CBN is more commonly found in aged cannabis. Although CBN has not been as extensively studied as other cannabinoids like CBD and THC, emerging research suggests that it has several potential therapeutic benefits, particularly for its sedative properties. Historically, it has been associated with inducing sleep, and recent studies support its potential efficacy in treating insomnia and other sleep-related issues.

Beyond its sedative effects, CBN is also being investigated for a range of other health benefits. Preliminary research indicates that CBN may possess anti-inflammatory, antibacterial, and analgesic properties. It has shown potential in stimulating appetite, which could be beneficial for patients dealing with conditions such as cancer or HIV/AIDS where appetite loss is a common issue. Furthermore, studies suggest that CBN might have neuroprotective qualities, offering promise for the treatment of neurodegenerative diseases like Alzheimer's. As research continues, CBN's unique properties and therapeutic potential are becoming more recognized, positioning it as an important cannabinoid in the development of medical cannabis products.

Cannabigerol (CBG) is a non-psychoactive cannabinoid found in the cannabis plant, often referred to as the "mother cannabinoid" because it is the precursor from which other cannabinoids like THC and CBD are synthesized. Although present in much smaller quantities than THC and CBD, CBG has garnered attention for its potential therapeutic properties. Research indicates that CBG may have a variety of health benefits, including anti-inflammatory, antibacterial, and neuroprotective effects. It is being studied for its potential in treating conditions such as inflammatory bowel disease, glaucoma, and Huntington's disease, as well as its potential to inhibit the growth of certain cancer cells. Its non-psychoactive nature makes it an appealing option for medical use, providing therapeutic benefits without the intoxicating effects associated with THC.

Cannabichromene (CBC), is a powerful, non-psychoactive cannabinoid, meaning it will not cause you to feel “high.” CBC, like THC and CBD, has been shown to encourage the human brain to grow by increasing the viability of developing brain cells in a process known as neurogenesis. CBC plays a significant role in the anti-cancer and anti-tumor capabilities of cannabis. CBC battles inflammation by activating the CB2 receptor. However, because it does not activate CB1, the healing potential of CBC could be enhanced when combined with cannabinoids that do, such as THC. 

Cannabis contains more than 150 types of terpenes. Although most terpenes are present in only trace amounts, the more prominent ones team together to give diverse cannabis strains their signature scent profiles. The combination of terpenes in Sour Diesel tell you of its pungent, gassy character, while Cherry Pie evokes the pleasant scent of sweet and sour cherry pie fresh out of the oven. 

Beyond providing cannabis with its unique bouquet of scents, terpenes also hold diverse functions in the plant and can produce a range of therapeutic and mood-altering effects in cannabis consumers.

Below is some info. on the 3 Terpenes that are the most prominent and some of their potential benefits.

Most cannabis cultivars are dominant in either myrcene or caryophyllene. Myrcene, a terpene that’s also predominant in hops and lemongrass, has been described as delivering scent notes that are herbaceous, spicy, earthy, and musky. Myrcene gives cannabis a mildly sweet flavor profile—it’s also found in mangoes. 

In addition to contributing to the signature scent of cannabis, myrcene can also deliver anti-inflammatory effects. A 2015 study of cultured cells indicates that myrcene may effectively reduce inflammation associated with osteoarthritis. 

The terpene also appeared to help prevent the breakdown of cartilage cells, slow down the progression of osteoarthritis, and decrease the production of certain inflammatory cells produced by the body. Myrcene could potentially be harnessed to help alleviate anti-inflammatory diseases and their symptoms in the future.

Continued in next column....

Caryophyllene also known as beta-caryophyllene or β-caryophyllene, lends a spicy, peppery bite to some cannabis strains. Caryophyllene is also found in other plants such as cloves, rosemary, oregano, and black pepper. If you catch any of these scents when you smell a certain cannabis cultivar, it’s likely because caryophyllene is present. 

Caryophyllene is the only known terpene found in cannabis that can bind to the CB2 receptor in the endocannabinoid system, which is found in the body’s immune system. Thanks to this unique action, caryophyllene is sometimes also classed as an atypical cannabinoid. 

Research into the therapeutic actions of caryophyllene shows that it has potential in easing symptoms in diverse conditions such as colitis, diabetes, cerebral ischemia, anxiety and depression, liver fibrosis, and Alzheimer-like diseases. 

Future research suggests that caryophyllene’s activity at the CB2 receptor could be harnessed to help treat conditions that are accompanied by inflammatory symptoms.

Clean, fresh, uplifting citrus-y scents—limonene’s name is a giveaway for the aromas associated with this terpene. Limonene is found in the rinds of citrus fruits and ginger, and the terpene is also predominant in many cannabis cultivars that have a fruity, fresh bouquet, like Papaya Punch or Black Cherry Soda. 

Limonene appears to alter the way certain immune cells in the body behave, which may protect the body from a range of disorders. In  one study limonene helped to increase the production of antibody-producing cells in the spleen and bone marrow, which are used by the immune system to identify and neutralize pathogenic bacteria and viruses. 

Researchers have also recently floated the idea that the unique therapeutic profile of limonene could be useful in treatments for COVID-19.